lack of association between transforming growth factor beta 1 -509c/t and +915g/c polymorphisms and chronic hepatitis b in iranian patients
نویسندگان
چکیده
objectives in this study, the association of tgf-β1 +915g/c and -509c/t gene polymorphisms with chronic hepatitis b was evaluated in iranian patients. materials and methods a population-based case–control study was conducted in taleghani hospital, tehran. a number of 220 patients with chronic hepatitis b and the same number of healthy control subjects were designated the case and the control groups. the pcr-restriction fragment length polymorphism method (pcr-rflp) method was used for genotyping both polymorphisms. ten percent of the control samples were sequenced to confirm the results. background chronic hepatitis b is one of the world's major health concern. the etiological agent of this infection is hepatitis b virus (hbv), which can evade the immune system response. transforming growth factor beta 1 (tgf-β1) can act against hbv by suppressing the viral replication. the tgf-β1 also plays an important role in preventing liver damage in chronically hbv infected patients. conclusions there was no association between tgf-β1 -509c/t and +915g/c polymorphisms with chronic hepatitis b and it seems that these changes don not play a significant role in increasing the risk of chronic infection in iranian patients. results no statically significant differences in genotype distribution and allele frequency were observed for both polymorphisms between healthy controls and patients with chronic hepatitis b.
منابع مشابه
Lack of Association Between Transforming Growth Factor Beta 1 -509C/T and +915G/C Polymorphisms and Chronic Hepatitis B in Iranian Patients
BACKGROUND Chronic hepatitis B is one of the world's major health concerns [corrected]. The etiological agent of this infection is hepatitis B virus (HBV), which can evade the immune system response. Transforming growth factor beta 1 (TGF-β1) can act against HBV by suppressing the viral replication. The TGF-β1 also plays an important role in preventing liver damage in chronically HBV infected p...
متن کاملcorrigendum to: lack of association between transforming growth factor beta 1-509c/t and +915g/c polymorphisms and chronic hepatitis b in iranian patients [published in hepatitis monthly. 2014 april; 14(4): e13100]
متن کامل
Corrigendum to: Lack of Association Between Transforming Growth Factor Beta 1-509C/T and +915G/C Polymorphisms and Chronic Hepatitis B in Iranian Patients [Published in Hepatitis Monthly. 2014 May; 14 (5): e13100]
متن کامل
Investigation of Transforming Growth Factor-β1 Gene Polymorphisms Among Iranian Patients With Chronic Hepatitis C
BACKGROUND Chronic hepatitis C infection is caused by the hepatitis C virus (HCV), and its clinical complications include liver cirrhosis, liver failure, and hepatocellular carcinoma.Transforming growth factor-β1 (TGF-β1) is an important cytokine in cell growthand differentiation, angiogenesis, extracellular matrix formation, immune responseregulation, and cancer development and progression. ...
متن کاملTransforming Growth Factor Beta 1 869T/C and 915G/C Polymorphisms and Risk of Autism Spectrum Disorders
Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression. The aim of the pres...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۴، شماره ۴، صفحات ۰-۰
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